Synonyms: 1,2-Dihydro-2-oxo-N-[3-[[(5-phenyl-3-isoxazolyl)carbonyl]amino]propyl]-3-pyridinecarboxamide; CID 60167648
Molecular Formula: C19H18N4O4
Molecular Weight: 366.37
Linear Structural Formula: C19H18N4O4
MDL Number: MFCD31619239
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: ML327 is a regulator of E-cadherin transcription that restores E-cadherin expression in cancer cell lines and partially reverses Epithelial-to-Mesenchymal Transition (EMT). It is a potent inducer of mesenchymal-to-epithelial transition (MET) in epithelial cancers. Apparently ML327 blocks MYC expression in neuroblastomas. It induces apoptosis in cancer cells and sensitizes Ewing sarcoma cells to TRAIL.