Synonyms: 3-[4-(2,3-Dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-pyrrolidin-1-ylbenzenesulfonamide; 3-[[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide; CID 2440433; CID-2440433; CID2440433; ML 184; ML-184
Molecular Formula: C25H34N4O3S
Molecular Weight: 470.63
Linear Structural Formula: C25H34N4O3S
MDL Number: MFCD06367291
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: ML184 (CID2440433) is a selective G-protein coupled receptor GPR55 (LPIR1) agonist (EC50 = 0.26 muM vs. >32 muM toward GPR35 & CB1/2 by cell-based betaarr2 recruitment assay; antagonist IC50 = 15.1, 21.8, >32 muM, respectively, against CB2, CB1, GPR35). ML184 is 18-times more potent than lysophosphatidylinositol in stimulating cellular ERK1/2 phosphorylation (GPR55E- & betaarr2-GFP-expressing U2OS cells) and is at least 10-times more potent than CID1792197 or CID1172084 (ML185) in inducing PKCbetaII translocation (GPR55E- & PKCbetaII-GFP-expressing HEK293 cells).