Synonyms: alpha-[(2-Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide; 2-Chloro-N-(3-chloro-4-methoxyphenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide; BRD-5421; BRD5421; CID 3689413; ML 162; ML-162; Molecular Libraries 162
Molecular Formula: C23H22Cl2N2O3S
Molecular Weight: 477.4
Linear Structural Formula: C23H22Cl2N2O3S
MDL Number: MFCD03450805
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: ML162 is a small molecule that induces ferroptosis via covalent inhibition of cellular phospholipid glutathione peroxidase (GPX-4; GPX4; GSHPx-4; PHGPx; snGPx; snPHGPx). Synthetic lethality studies in cancer cultures identify contributing factors such as HRas(G12V) expression and fumarate hydratase (FH) deletion to ML162 sensitivity (IC50 = 25 nM & 35 nM, respectively, in BJeLR-HRas(G12V) & UOK262-FH-/- cultures).