Synonyms: Dithio-(Rp, Rp)-2',3'-CDA sodium salt; Dithio-(Rp, Rp)-2',3'-c-diAMP sodium salt; Dithio-(Rp, Rp)-2',5'-3',5'-c-diAMP sodium salt; Dithio-(Rp, Rp)-[cyclic[A(2',5')pA(3',5')p]] sodium salt
Molecular Formula: C20H24N10O10P2S2 · xNa+
Linear Structural Formula: C20H24N10O10P2S2 · xNa+
Purity: >=95% (HPLC)
Storage: -20C
Biochem Physiol Actions: ML-RR-S2 CDA is a potent STING-activating cyclic di-adenosine (CDA or c-diAMP) nucleotide ligand with the 2′-5′, 3′-5′ mixed phosphodiester linkage (ML) in the [Rp,Rp] configuration and doubly substituted thiophosphate (S2) for optimal phosphodiesterase-resistance and thereby enhanced cellular potency. ML-RR-S2 CDA effectively induces IRF3, NF-kB, and STAT6 transcription activities in a STING-dependent manner in both murine (DC2.4 & BMMs) and human (THP1 & PBMCs) cultures (5-100 μM) as well as displays profound anti-tumor efficacy in vivo (100% growth inhibition of established B16.F10, 4T-1 or CT26 tumor with 3X 50 μg/mouse/96 hr intratumoral injections) with lasting immune-mediated tumor rejection.