An ATP-competitive inhibitor of the D2 domain of the p97 ATPase (IC50 = 0.11 µM; Ki = 0.22 µM); disrupts ERAD and autophagy pathways; blocks proliferation of HCT15 and SW403 colon cancer cell lines (GI50s = 0.76 and 0.5 µM, respectively) rapidly mobilizing caspase-3 and -7 to induce apoptosis.