2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a derivative of the synthetic isothiazolinone.
Synonyms: Methylisothiazolinone hydrochloride
Storage: 2-8C
Application:
•Methylisothiazolinone (MIT) has been used as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and role in apoptotic cell death.
•MIT is used to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites.
•MIT is an efficient antifungal and antibacterial, and a substitute to thimerosal.
Biochem Physiol Actions: 2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a skin sensitizer known to cause contact dermatitis and allergy. It is extensively used in the cosmetic industry as a preservative. MIT is a neurotoxin and its prolonged exposer may lead to neuronal death and inhibition of neurite outgrowth. It is also a potent antibacterial agent.