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Synonyms: (+/-)-Miconazole nitrate salt; 1-(2,4-Dichloro-beta-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole
Molecular Formula: C18H14Cl4N2O · HNO3
Molecular Weight: 479.14
Linear Structural Formula: C18H14Cl4N2O · HNO3
MDL Number: MFCD00058161
Storage: 2-8C
Biochem Physiol Actions: Miconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.
Other Notes: Sales restrictions may apply.