Synonym: Compactin, ML-236B
CAS Number: 73573-88-3
Empirical Formula (Hill Notation): C23H34O5
Molecular Weight: 390.51
Beilstein Registry Number: 1269441
MDL Number: MFCD05662341
PubChem Substance ID: 24278540
Biochem/physiol Actions
HMG-CoA reductase inhibitor. Cholesterol lowering drug. Inhibits myoblast formation. An antibiotic shown to cause apoptosis, apparently by inhibiting post-translational prenylation of proteins such as Ras. Similarly, mevastatin increases eNOS mRNA and protein levels by blocking the geranylgeranylation of Rho.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Assay: =95% (HPLC)
Form: powder
Color: white
Solubility: DMSO: soluble20 mg/mL; ethanol: soluble25 mg/mL
Storage Temp.: 2-8°C
Gene Information: human ... HMGCL, HMGCR; rat ... Hmgcr