Synonyms: Dimesityl(trifluoromethyl)sulfonium trifluoromethanesulfonate; MacMillan trifluoromethylation reagent; dMesSCF3 reagent
Molecular Formula: C20H22F6O3S2
Molecular Weight: 488.51
Linear Structural Formula: C20H22F6O3S2
Purity: >=95%
Storage: -20C
Application: Under a dual catalytic copper/photoredox manifold, the Mes-Umemoto reagent has been demonstrated by the MacMillan lab to be an excellent reagent for the trifluoromethylation of alkyl halides and aryl halides to yield alkyl-CF3 and aryl-CF3 in high yields. In both cases, these reactions exhibit wide substrate scope with good functional group tolerance. More specifically, a variety of 5-membered and 6-membered heteroaryl halides can be readily converted to the corresponding trifluoromethylheteroarenes under mild conditions. To be use in conjunction with supersilanol (902489) and Ir photocatalyst (902217 or 902225).
Other Notes: A radical approach to the copper oxidative addition problem:Trifluoromethylation of bromoarenes