Synonyms: 5-(4-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-1H-imidazol-2-amine; Malat1 inhibitor compound 5; N-(3-Methoxybenzyl)-5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-amine; TC SL C5
Molecular Formula: C19H21N3O2
Molecular Weight: 323.39
Linear Structural Formula: C19H21N3O2
MDL Number: MFCD06011226
Purity: >=95% (HPLC)
Storage: -20C
Biochem Physiol Actions: MALAT1-IN-5 reduces the long noncoding (lnc) RNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) level (by 54% in 7 days at 1 muM; MMTV-PyMT tumors organoids) via specific interaction with Malat1 triple-helical configuration of 3'-terminal element for nuclear expression (ENE KD = 2.9 muM under physiologic ionic conditions), but not the homologous 3'-end triple-helix of Neat1 (MENbeta) lncRNA. MALAT1-IN-5 decreases MMTV-PyMT organoid branching morphogenesis (by 38% in 7 days at 1 muM) and modulates the levels of Malat1-targeted mRNAs Krt16 & Csn2.