Macelignan is a naturally occurring compound that has scavenging effects on free-radicals and inhibits prostaglandin. It also exhibits antioxidant and anti-inflammatory effects.
Synonyms: (+)-Anwulignan; 4-[(2S,3R)-4-(1,3-Benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxy-phenol; Anwulignan
Molecular Formula: C20H24O4
Molecular Weight: 328.4
Linear Structural Formula: C20H24O4
MDL Number: MFCD09953803
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Macelignan is a neuroprotective lingan isolated from nutmeg (Myristica fragrans) that protects dopaminergic neurons from inflammatory degeneration. Apparently, the neuroprotective effect of macelignan is mediated by PPARgamma activation and arginase-1 expression. Macelignan inhibits LPS induced production of NO as well and inflammatory cytokines including TNF and IL- 1beta in primary cultures of microglia.