Synonyms: (S)-3-Fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide; 3-Fluoro-4-[4-[[(2S)-2-(3-fluorophenyl)-1-pyrrolidinyl]methyl]phenoxy]benzamide; 4-[4-[[(2S)-2-(3-Fluorophenyl)-1-pyrrolidinyl]methyl]phenoxy]-3-fluorobenzamide; FP3FBZ; LY 2444296; LY-2444296
Molecular Formula: C24H22F2N2O2
Molecular Weight: 408.44
Linear Structural Formula: C24H22F2N2O2
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: LY2444296 is a brain-penetrant, orally active, short-acting, high-affinity, potent and selective kappa (kappa) opioid receptor (KOR) antagonist (human kappa/mu/delta Ki = 0.565/35.8/211 nM against diprenorphine binding; GTP-gamma-S binding IC50/agonist/subtype transfectant = 1.57 nM/300 nM U69593/kappa, 21.3 nM/1 muM DAMGO/mu 293 nM/30 nM DPDPE/d). LY2444296 reverses kappa agonist antinociceptive efficacy in vivo (ED50 = 0.24 mg/kg p.o. against 1 mg/kg U69593 sc. by rat formalin test), decreases immobility time (10 or 30 mg/kg sc.) and prevents enhanced alcohol consumption (5 mg/kg i.p.) among mice subjected to stress by forced swimming.