Synonyms: 6-Chloro-N4-cyclopropyl-N4-(2-thienylmethyl)-2,4-pyrimidinediamine; RU-0204277
Molecular Formula: C12H13ClN4S
Molecular Weight: 280.78
Linear Structural Formula: C12H13ClN4S
MDL Number: MFCD23148480
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: LRE1 is a selective allosteric inhibitor of soluble adenylyl cyclase (sAC), a ubiquitously expressed, essential component of cAMP-signaling. In contrast to G-protein-regulated transmembrane adenylyl cyclase, soluble adenylyl cyclase is directly activated by calcium and carbonate, and is dispersed throughout the cell cytoplasm. LRE1 was found to bind to the bicarbonate activator binding site. It inhibited cAMP accumulation in 4-4 cells with an IC50 of 11 muM, similar to that of KH7 and without its cellular toxicity.