Synonyms: 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid 4-cyano-benzylamide; N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide; N-[(4-Cyanophenyl)methyl]-4-[1,1'-biphenyl]-2-yl-1-piperazinehexanamide
Molecular Formula: C30H34N4O
Molecular Weight: 466.62
Linear Structural Formula: C30H34N4O
MDL Number: MFCD22690843
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.