The LOX-IMVI human melanoma cell line is widely used as an in vitro model system to study tumor metastasis and to test for chemosensitivity to potential anti-cancer compounds. LOX-IMVI cells exhibit a tendency to form lung metastases in nude mice independent of the inoculation site , and mortality of experimental animals is observed within 3-5 weeks of LOX-IMVI cell injection . LOX-IMVI cells are genetically characterized by lack of the Y chromosome and trisomy 7 , and are heterozygous for the BRAF V600E melanoma driver mutation . LOX-IMVI cells are amelanotic and express the human melanoma marker GD3 ganglioside, a factor in metastatic potential of malignant melanoma . Source: The LOX-IMVI human melanoma cell line was established from a subcutaneous xenograft in nude mice from a lymph node metastasis of a 58-year-old Caucasian male patient with malignant amelanotic melanoma .
Synonyms: LOX/IMVI, LOX IMVI, LOXIM-VI, LOXIMVI
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