Synonyms: 1-[(1Z)-2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole; 1-[(Z)-2-Chloro-2-(2,4-dichlorophenyl)vinyl]-1,2,4-triazole; R 72063; R-72063; R72063
Molecular Formula: C10H6Cl3N3
Molecular Weight: 274.53
Linear Structural Formula: C10H6Cl3N3
MDL Number: MFCD00865331
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: Loreclezole (R72063) is a sedative and anticonvulsant that exerts subtype-selective positive allosteric modulator (PAM) potency toward beta2 (beta2)- or beta3-containing GABAA gamma-aminobutyric acid (GABA) receptors (% potentiation by 1 muM Loreclezole of GABA EC20-stimulated current/human alpha1betagamma2 = 100/alpha1beta2gamma2, 120/alpha1beta3gamma2, 13/alpha1beta1gamma2; alpha1beta2gamma2 EC50 = 1 muM) with >300-fold lower beta1 affinity, while acting as a negative allosteric modulator (NAM) against the homomeric rho1 (ρ1) GABAA-rho receptor (rat GABAC IC50 = 0.5 muM against GABA EC10-induced current).