Lonafarnib (SCH66336) is a farnesyl transferase inhibitor (FTI). K- and N-Ras are substrates of farnesyl transferase.
Synonyms: 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5Hbenzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide; SCH-66336; SCH66336
Molecular Formula: C27H31Br2ClN4O2
Molecular Weight: 638.82
Linear Structural Formula: C27H31Br2ClN4O2
MDL Number: MFCD06795138
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: Lonafarnib prevents the post-translational lipid modification of H-Ras and other farnesylated proteins. Lonafarnib treatment results in microtubule bundling, increased microtubule acetylation and stabilization and suppression of microtubule dynamics.