Synonyms: AEGR-733; BMS-201038; N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]2-yl]carbonyl]amino]-1-piperidinyl]butyl]9H-fluoren-9-carboxamde
Molecular Formula: C39H37F6N3O2
Molecular Weight: 693.72
Linear Structural Formula: C39H37F6N3O2
MDL Number: MFCD16620494
Purity: >=98% (HPLC)
Storage: 2-8C
Application: Lomitapide has been used as a microsomal triglyceride transfer protein (MTP) inhibitor to study its effects on very-low-density lipoproteins (VLDL) export in mouse hepatocytes.
Biochem Physiol Actions: Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP). Lomitapide has been shown to be highly effective in reducing LDL-cholesterol and triglycerides, and has been aproved for treatment of homozygous familial hypercholesterolemia.