Synonyms: N-[4-(Aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)-1-piperazinecarbothioamide
Molecular Formula: C20H24N4O2S2
Molecular Weight: 416.56
Linear Structural Formula: C20H24N4O2S2
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: LF3 is a potent inhibitor of Wnt/beta-catenin signaling that suppresses cancer cells motility, cell-cycle progression, and the overexpression of Wnt target genes. LF3 is a potent and specific antagonist of the interaction between beta-catenin and the transcription factor TCF4. LF3 blocks self-renewal of cancer stem cells.