Leupeptin is an organic compound produced by actinomycetes, serine and cysteine proteases reversibly. Inhibits trypsin-like proteases and some cysteine proteases including endoproteinase Lys-C, Kallikrein, papain, thrombin, cathepsin B and trypsin. MW:426.56 s 49.04 . 18.02 {C20H36N6O4 . 1/2H2SO4 . H2O} Ac-Leu-Leu-Argininal (hemi-sulfated form). Thus material has three tautomeric isomers that can be visualized by chromatography. Appearance: White amorphous powder Working range 10-100muM. Stable for several hours in water. Stock solutions of 10mM in water are stable for 1 week at 4ºC and 6 months at -20ºC. 5mg/1.054 mL = 10mM. Typically dilute 1:100 for a 100muM working solution. Source: Organic isolated from actinomycetes.
Biochem Physiol Actions: Inhibitor Type: Protease Inhibitors
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