Synonyms: (3E,5E)-1-ethyl-3,5-bis[(2,3,4-trimethoxyphenyl)methylidene]piperidin-4-one; 1-Ethyl-3,5-bis(3,4,5-trimethoxybenzylidene)piperidin-4-one; 1-Ethyl-3,5-bis[(2,3,4-trimethoxyphenyl)methylene]-4-piperidinone
Molecular Formula: C27H33NO7
Molecular Weight: 483.55
Linear Structural Formula: C27H33NO7
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: L48H37 is a potent and chemically stable anti-inflammatory curcumin analog that inhibits LPS-induced inflammation through the myeloid differentiation 2 (MD-2) and toll-like receptor 4 (TLR4) complex. L48H37 is a potent MD2 inhibitor that binds to the hydrophobic region of MD-2 and blocks the interaction between MD2 and LPS. L48H37 significantly improves survival and protected lung injury in LPS-induced septic mice.