Synonym: 3,3',5,5?-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T4
CAS Number: 51-48-9
Linear Formula: HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
Molecular Weight: 776.87
Beilstein Registry Number: 2228515
EC Number: 200-101-1
MDL number: MFCD00002595
PubChem Substance ID: 24900033
Biochem/physiol Actions
L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.
L-Thyroxine is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells. L-Thyroxine reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints. Hence, facilitates in improving cardiovascular risk factor as well as can enhance symptoms of tiredness.
Preparation Note
L-Thyroxine dissolves in 4M ammonium hydroxide in Methanol at 50 mg/ml to yield a clear to hazy yellow to dark yellow solution.
Application
L-Thyroxine was used to study the light-induced hormone conversion of T4 to T3 in regulation of photoperiodic response of gonads in Japanese quail.1 The product was used as a test compound for studying the impact of numerous hormones on the surface morphology of rat testicular cells in culture.2
Bottomless glass bottle. Contents are inside inserted fused cone.
assay: =98% (HPLC)
mp: 223 °C (dec.)(lit.)
density: 0.92 g/mL at 20 °C(lit.)
storage temp.: room temp