L-lactate dehydrogenase (LDH) is an enzyme that catalyzes the conversion of lactate to pyruvate
•In particular, lactic dehydrogenase A (LDHA) is mainly found in skeletal muscle, and for that reason is known as the M subunit. This recombinant form of LDHA has a C-terminal histidine-tag.The gene LDHA (L-lactate dehydrogenase A chain) is mapped to human chromosome 11p15. It is a subunit of lactate dehydrogenase.
Synonyms: Lactic Dehydrogenase, recombinant from E. coli; (S)-Lactate: NAD+ oxidoreductase; L-Lactate Dehydrogenase; Lactate
MDL Number: MFCD00131466
Storage: -20C
Biochem Physiol Actions: L-lactic dehydrogenase catalyzes the conversion of L-lactate into L-pyruvate while reducing NAD+ to NADH and H+.LDHA (L-lactate dehydrogenase A chain) is responsible for the conversion of pyruvate to lactate, the final step of glycolysis. It is overexpressed in various cancers. In cancer cells, HIF-1a (hypoxia-inducible factor) induces the expression of LDHA, which helps in maintaining glycolysis in cells.