Synonyms: (4-Hydroxy-7-isopropylbenzo[d]isoxazol-5-yl)(isoindolin-2-yl)methanone
Molecular Formula: C19H18N2O3
Molecular Weight: 322.36
Linear Structural Formula: C19H18N2O3
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: KUNB31 is an isoform-selective inhibitor of Hsp90beta with an IC50 value of 180 nM and > 50-fold selectivity over closely related isoforms Hsp90alpha and GRP94.Hsp90 inhibitors currently in clinical trials are all pan-inhibitors with multiple side effects including induction of the pro-survival heat shock response. KUNB31 was shown to induce the degradation of Hsp90beta-dependent client proteins, but not those of Hsp90alpha and GRP94, and did not induce production of Hsp90. It showed anti-proliferative activity against NCI H23 (non-small cell lung cancer), UC3 (bladder cancer), and HT-29 (colon adenocarcinoma) cells with low micromolar IC50 values, while requiring more than 100 muM against non-cancerous human embryonic kidney HEK-293 cells.