Synonyms: (2R,6S)-rel-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide
Molecular Formula: C30H33N3O5S
Molecular Weight: 547.67
Linear Structural Formula: C30H33N3O5S
MDL Number: MFCD19690944
Purity: >=97% (HPLC)
Storage: -20C
Application: KU-60019 has been used to block ataxia telangiectasia mutated (ATM), to study its association of with the regulation of H2AX (H2A histone family, member X) and apoptosis inducing factor (AIF)-mediated cell death.
Biochem Physiol Actions: KU-60019 is a potent inhitor of ATM (ataxia telangiectasia mutated) kinase, a member of phosphatidylinositol-3-kinase-related kinase family that is critical in regulating cell cycle checkpoints and DNA repair. KU-60019 has an IC50 value of 6.3 nM. KU-60019 radiosensitizes U1242 human glioma cells, and also blocks U1242 cell migration and invasion through matrigel.
Other Notes: KU-60019 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the KU-60019 probe summary on the Chemical Probes Portal website.