A selective, potent agonist of EP4 with an IC50 value of 3 nM (versus 1.4 μM for EP3 and > 10 μM for all other prostanoid receptors) and an EC50 value of 0.19 nM in functional assays; induces the differentiation of bone marrow stem cells from both young and aged rats into osteoblasts in vitro (EC50s = 20 and 153 nM, respectively); repairs calvarial defects in an in vivo rat craniomaxillofacial reconstruction model and promotes bone formation in a rat incisor tooth socket model.