Synonyms: N-(5-Chloro-2-methylphenyl)-4-(4-fluorophenyl)-2-hydroxy-4-oxo-2-butenamide
Molecular Formula: C17H13ClFNO3
Molecular Weight: 333.74
Linear Structural Formula: C17H13ClFNO3
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: KL-2 is a disruptor of the super elongation complex (SEC). KL-1 blocks the interactions of positive transcription elongation factorb (P-TEFb) and the SEC-scaffolding protein AFF4 resulting in decreased Polymerase II (Pol II) activity and production of Pol II-transcribed genes. KL-2 was shown to cause downregulation of heat shock genes, and was non-toxic and active in an animal model of cancer.