Synonyms: N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide
CAS Number: 927822-86-4
Formula: C16H16Cl4N2O4S4
Formula Weight: 570.38
Linear Formula: C16H16Cl4N2O4S4
MDL No.: MFCD22683809
Purity: >=98% (HPLC)
Storage: -20C
UNSPSC Code: 12352200
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Biochem/physiol Actions: KC7F2 is a cell permeable potent HIF-1 pathway inhibitor. KC7F2 inhibits the activation of HIF-target genes such as carbonic anhydrase IX, matrix metalloproteinase 2 (MMP2), enolase 1, and endothelin 1. KC7F2 suppresses the protein accumulation of HIF-1? in cancer cell lines by inhibition of its protein synthesis at the translation level. KC7F2 is preferentially cytotoxicity to cancer cells, an effect that is increased in hypoxia.
Other Notes: air sensitive
RIDADR: NONH for all modes of transport
WGK Germany: 3
R Codes: 36/37/38
S Codes: 26
IOD Codes: Xi