Synonym: 3,4',5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, Robigenin
CAS Number: 520-18-3
Empirical Formula (Hill Notation): C15H10O6
Molecular Weight: 286.24
Beilstein Registry Number: 304401
MDL Number: MFCD00016938 0
PubChem Substance ID: 24896195
Application
Chromogenic reagent for antimony in the low ppm range and for gallium and indium in the sub-ppm range.
Biochem/physiol Actions
A flavonol shown to revert the transformed phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH 3T3 cells. Induces significant nuclear DNA degradation concurrent with lipid peroxidation. Inhibits topoisomerase I catalyzed DNA religation. Kaempferol may also inhibit the activity of fatty acid synthase.
Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Assay: =90% (HPLC)
Form: powder
Storage Condition: protect from light
Color: yellow
Solubility: ethanol: soluble20 mg/mL; DMSO: soluble50 mg/mL
Storage Temp.: room temp
Gene Information: human ... CDC2(983); CDK5(1020), CDK6(1021), CYP1A2(1544), CYP2C9)1559), GSK3A(2931); mouse ... Hexa(15211)