Synonyms: 4-[[(3E,5S)-5-[[(1,1-Dimethylethoxy)carbonyl]amino]-7-methyl-1-oxo-3-octen-1-yl]amino]-2,2,6,6-tetramethyl-1-piperidinyloxy; JP 4-039
Molecular Formula: C23H42N3O4
Molecular Weight: 424.6
Linear Structural Formula: C23H42N3O4
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: JP4-039 is an electron-/reactive oxygen species (ROS)-scavenging GS-nitroxide composed of 4-amino-TEMPO and a truncated gramicidin S (GS) mitochrondria-targeting sequence. JP4-039 is a superior irradiation mitigator than XJB-5-131 (33% vs. 20% mice survial rate on day 35 with respective compound; 23.6 mumol/kg iv. 24 hr post 9.5 Gy whole body irradiation), while displaying weaker anti-ferroptotic potency (EC50 = 3.58 muM/1.27 muM against 10 muM erastin-/2 muM RSL3-induced HT-1080 ferroptosis vs. 114 nM/68 nM with XJB-5-131) due to lower lipophilicity & mitochondria enrichment. Typical dosing range: 40 nM-10 muM in cultures and 10-20 mg/kg in mice (im., ip., iv.) in vivo.