Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Synonyms: Isoniazid; 4-Pyridinecarboxylic acid hydrazide; INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide
Molecular Formula: C6H7N3O
Molecular Weight: 137.14
Linear Structural Formula: C6H7N3O
MDL Number: MFCD00006426
Melting Point: 171-173 C (lit.)
Biochem Physiol Actions: Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.
Other Notes: This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.