Antigen: synthetic peptide corresponding to a mixture of mouse IRAK-4 amino acids 38-54 and 120-136
Host: rabbit
Cross Reactivity: (+) human and mouse IRAK-4
Application(s): IP and WB
IRAK-4 may act as an upstream activator of IRAK-1 and is important for LPS activation of TLRs. Mice lacking IRAK4 are resistant to lethal doses of LPS and are also severely impaired in their responses to viral and bacterial challenges.