Specific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A beta-secretase inhibitor that inhibits beta-amyloid peptide (Abeta) production and enhances amyloid precursor protein (sAPPUalpha) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications.
Synonyms: InSolution AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem; 4-(2-Aminoethyl)benzenesulfonylfluoride, HCl, 4-(2-Aminoethyl)benzene-1-sulfonylfluoride, HCl, AEBSF, HCl InSolution
Molecular Formula: C8H10FNO2S · xHCl
Linear Structural Formula: C8H10FNO2S · xHCl
MDL Number: MFCD00132962
Purity: >=97% (HPLC)
Biochem Physiol Actions: Reversible: no
Legal Information: CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes: Citron, M., et al. 1996. Neuron17, 171.Ohkubo, I., et al. 1994. J. Biochem.116, 1182.Mintz, G.R. 1993. BioPharm.6, 34.Lawson, W.B., et al. 1982. Folia Haematol.109, 52.Markwardt, F., et al. 1974. Biochem. Pharmacol.23, 2247.Markwardt, F., et al. 1973. Thromb. Res.2, 343.Baker, B.R., and Cory, M. 1971. J. Med. Chem.14, 119.