Human Interferon gamma (hIFN-?) is amacrophage-activating factor and the lone member of Interferon type II.The active form of IFN-? is an antiparallel dimer that interacts with the receptor IFN-?R1 and sets off IFN-?/JAK/STAT pathway. IFN-? signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity. While IFN-?–induced inflammatory cascade summons a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-? is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers.
Recombinant human Interferon gamma (rhIFN-?) produced in E. coli is a non-glycosylated polypeptide chain of 144 amino acids. A fully biologically active molecule, rhIFN-? has a molecular mass of 17 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques at GenScript.