Animal-free Recombinant Human PDGFbb is a growth factor that promotes blood vessel formation, mitogenesis, chemotaxis, etc. The PDGF family members (four homodimers and one heterodimer) are secreted, disulfide-linked dimeric glycoproteins that regulate their cellular functions through interaction with PDGFR (a and b) receptors. PDGFbb is synthesized, stored, and released by alpha granules of platelets. It is also known as PDGF-2, becaplermin, or GDGF. Dysregulation in PDGF signaling has been shown to be associated with tumorigenesis and progression of cancer. Recombinant PDGFbb is used in treatment of chronic ulcers and to speed healing in surgical procedures.