Synonyms: 2, 4-Disulfonyl PBN; 2,4-Disulfophenyl-N-tert-butylnitrone; ARL 16556; CPI 22; Cerovive; Disodium 4-[(tert-butyl-imino) methyl]benzene-13-disulfonate N-oxide; Disufenton sodium; NXY-059; Nxy 059; OKN-007; OKN007; Oklahoma nitrone-007
Molecular Formula: C11H13NO7S2 · 2Na
Molecular Weight: 381.33
Linear Structural Formula: C11H13NO7S2 · 2Na
MDL Number: MFCD09833648
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: Originally characterized for its NO-mimicking activity in preventing peroxynitrite formation and in vivo neuroprotective efficacy in animal models of cerebral ischemia (100 mg/kg i.v. in rabbits; 30-60 mg/kg plus 30-60 mg/kg/h i.v. or 50 mg/kg plus 8.8 mg/kg/h s.c. in rats; 28 mg/kg plus 16 mg/kg/h i.v. in monkeys), OKN-007 (HPN-07, NXY-059) is an orally available α-phenyl-tert-butylnitrone (PBN) derivative that is also shown to exhibit sulfatase 2 (SULF2) inhibitory activity and anticancer efficacy both in cultures (effective conc. 170-200 μM in Huh7 heptoma cultures) and in several rodent glioma models in vivo (C6, RG2, and GL261; 75 mg/kg/day for rats and 168 mg/kg/day for mice via drinking water).