A cell-permeable second generation hybrid polar agent that acts as a histone deacetylase (HDAC) inhibitor. The HDAC inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Shown to be a potent inducer of transformed cell growth arrest and terminal differentiation (~4 µM). Induces apoptosis and the CD95/CD95-Ligand expression in human neuroblastoma.
Synonyms: Histone Deacetylase Inhibitor II - CAS 174664-65-4 - Calbiochem; CBHA, m-Carboxycinnamic Acid bis-Hydroxamide; CBHA, m-Carboxycinnamic Acid bis-Hydroxamide
Molecular Formula: C10H10N2O4
Molecular Weight: 222.2
Linear Structural Formula: C10H10N2O4
Purity: >=95% (HPLC)
Biochem Physiol Actions: Reversible: no
Legal Information: Not available for sale in the United States.
Other Notes: Coffey, D.C., et al. 2001. Cancer Res.61, 3591.Coffey, D.C., et al. 2000. Pediatr. Oncol.35, 577.Marks, P.A., et al. 2000. J. Natl. Cancer Inst.92, 1210.Glick, R.D., et al. 1999. Cancer Res.59, 4392.Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA95, 3003.Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 5705.