Herpes Simplex Virus Type II Monoclonal Antibody

Background

Herpes simplex type 2 (HSV2) belongs to a family that includes HSV1, Epstein-Barr virus (EBV) and Varicella zoster (chicken pox) virus. HSV1 and HSV2 are extremely difficult to distinguish from each other. The HSV-1 strain generally appears in the orafacial organs. HSV2 usually resides in the sacral ganglion at the base of the spine. These viruses have a large DNA genome, capsid, and a lipid bilayer membrane derived from the nuclear membrane of the last host. These viruses are capable of entering a latent phase where the host shows no visible sign of infection. Envelope glycoprotein C (gC) and glycoprotein B (gB) bind to cell surface partials heparin sulfate. Receptor binding protein glycoprotein D (gD) binds to HVEM, nectin-1, and 3-O sulfated heparin sulfate forming complexes with glycoprotein H (gH) and glycoprotein (gL) creating an entry pore for the viral capsid.

Application Note

Anti-Herpes Simplex Virus Type II (HSV2) (MOUSE) Monoclonal Antibody was tested with IHC-P positive control infected lung tissues. Cellular Localization: Cytoplasmic, nuclear. The user is advised to validate the use of the products with their tissue specimens prepared and handled in accordance with their laboratory practices. Consult references (Kiernan, 1981: Sheehan & Hrapchak, 1980) for further details on specimen preparation.

Purity/Specificity

The antibody is supplied as a purified immunoglobulin. This antibody reacts with herpes simplex virus type 2. It is specific for the viral glycoprotein D (gD) protein.