Herpes Simplex Virus Type I Polyclonal Antibody

Background

The herpes simplex (HSV) (also known as cold sore, night fever or fever blister) is a virus that causes a contagious disease. There are two main types of Herpes Simplex Virus (HSV) , 1 and 2; and they belong to a family that includes Epstein-Barr virus (EBV) and Varicella zoster (chicken pox) virus. HSV1 and HSV2 are extremely difficult to distinguish from each other. The HSV-1 strain generally appears in the orafacial organs. HSV2 usually resides in the sacral ganglion at the base of the spine. These viruses have a large DNA genome, capsid, and a lipid bilayer membrane derived from the nuclear membrane of the last host. These viruses are capable of entering a latent phase where the host shows no visible sign of infection. Envelope glycoprotein C (gC) and glycoprotein B (gB) bind to cell surface partials heparin sulfate. Receptor binding protein glycoprotein D (gD) binds to HVEM, nectin-1, and 3-O sulfated heparin sulfate forming complexes with glycoprotein H (gH) and glycoprotein (gL) creating an entry pore for the viral capsid.

Application Note

Anti-Herpes Simplex Virus Type I Antibody was tested in IHC-P with positive control infected tissues. Consult references (Kiernan, 1981: Sheehan & Hrapchak, 1980) for further details on specimen preparation. The user is advised to validate the use of the products with their tissue specimens prepared and handled in accordance with their laboratory practices.

Purity/Specificity

This antibody reacts with the HSV type 1 specific antigen. It is suitable for detection of HSV in human cellular material obtained from superficial lesions or biopsies and for the early identification of HSV in infected tissue cultures. The antibody is supplied as a purified immunoglobulin.