Synonyms: (S)-1,2,5-Triazaspiro[2.4]hept-1-ene-6-carboxylic acid; Diazirine amino acid; Photo-Pro; Photo-crosslinking amino acid; Photoprobe building block
Molecular Formula: C5H8ClN3O2
Molecular Weight: 177.59
Linear Structural Formula: C5H8ClN3O2
Purity: >=95%
Storage: -20C
Application: H-L-Photo-Proline HCl is a diazirine-containing proline amino acid and multifunctional probe building blocks. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (>=360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907324.
Other Notes: Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe SynthesisPhoto-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)