Synonym: 3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
CAS Number: 405911-17-3
Empirical Formula (Hill Notation): C33H31F3ClNO3 · HCl
Molecular Weight: 618.51
MDL Number: MFCD08276920
PubChem Substance ID: 24724494
Biochem/physiol Actions
GW3965 is a liver X receptor full agonist on hLXRa and hLXRß. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRa and profiles as a full agonist on hLXRa and hLXRß in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.
Assay: =98% (HPLC)
Form: powder
Color: white
Solubility: DMSO: =20 mg/mL