Guanfacine-13C,15N3 is intended for us as an internal standard for the quantification of guanfacine (Item No. 22907) by GC- or LC-MS. Guanfacine is an a2-adrenergic receptor (a2-AR) agonist with Ki values of 93, 1,380, and 3,890 nM for a2A-, a2B-, and a2C-ARs, respectively, in a radioligand binding assay.{40326} It has EC50 values of 52, 288, and 602 nM for a2A-, a2B-, and a2C-ARs, respectively, for stimulated [35S]GTP?S binding. It also binds to imidazoline receptor 1 (Ki = 19 nM in a radioligand binding assay).{40341} Guanfacine (0.3-5 mg/kg) binds to adrenergic receptors in the central nervous system and lowers blood pressure in hypertensive rats in a dose-dependent manner.{40342} It also improves spatial working memory deficits induced by hypobaric hypoxia in rats.{40340} Formulations containing guanfacine are used in the treatment of high blood pressure and attention deficit hyperactivity disorder (ADHD).
Technical Information
CAS Number
454-29-5
Synonyms
NSC 206252
Molecular Formula
C4H9NO2S
Formula Weight
135.2
Purity
90%
Formulation
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A crystalline solid
Solubility
(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
SCCC(N)C(O)=O
InChi Code
InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)
InChi Key
FFFHZYDWPBMWHY-UHFFFAOYSA-N
Shipping & Storage Information
Storage -20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
Shelf life: 4 years