Synonyms: 3-(5-Benzothiazolyl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)-thieno[3,2-c]pyridin-4-amine; GSK 843; GSK-843; GSK843
Molecular Formula: C19H15N5S2
Molecular Weight: 377.49
Linear Structural Formula: C19H15N5S2
MDL Number: MFCD30536593
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: GSK'843 is a potent ATP-competitive RIP3 (RIPK3) kinase inhibitor (IC50 = 6.5 nM) with much reduced or little affinity toward 262 other kinases (IC50 >1 muM against 10 muM ATP in competitive binding assay), including RIP5. GSK'843 effectively suppresses TNF/Z-VAD-FMK/IAP agonist treatment-induced necrosis induction in both human and murine cell cultures (EC50 ranges from<0.12 to 3 mum), while inducing apoptosis in the absence of caspase inhibitor as a result of caspase 8 activation via rhim-driven recruitment to assemble a casp8-fadd-cflip complex independent of pronecrotic kinase activities and mlkl.<>