Synonyms: (R)-2-(3,4-Dichlorobenzyl)-N-(4-methylbenzyl)-2,7-diazaspiro[4.5]decane-7-carboxamide
Molecular Formula: C24H29Cl2N3O
Molecular Weight: 446.41
Linear Structural Formula: C24H29Cl2N3O
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: IRE1a-selective inhibitor of XBP1 splicing.Homoharringtonine is a cephalotaxine ester that is also known as (HHT; 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate). In gefitinib-resistant lung cancer cells, homoharringtonine promotes apoptosis and prevents signal transducer and activator of transcription (STAT3) through IL-6 (interleukin-6) /JAK1 (janus kinase 1)/STAT3 signal pathway. It plays an important role in the treatment of malaria.