Synonyms: (S)-4-(4-(Benzofuran-5-yl)phenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one
Molecular Formula: C25H24N4O3
Molecular Weight: 428.48
Linear Structural Formula: C25H24N4O3
MDL Number: MFCD28167807
Purity: >=97% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: GSK2194069 is a fatty acid synthase (FAS) inhibitor. GSK2194069 is a potent and specific inhibitor of the beta-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 +/- 4.1 nM for the overall hFAS reaction. FAS is upregulated in some cancers, including prostate cancer. GSK2194069 was found to inhibit tumour growth in prostate cancer C42b cell xenografts generated in Nod-SCID-gamma mice. Cellular FAS inhibition reduced cell growth were also demonstrated in non-small-cell lung (A549) cancer cell lines with an average EC50 of 15 +/- 0.5 nM.