Synonyms: 1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one; GSK-2934A
Molecular Formula: C22H25N3O2S
Molecular Weight: 395.52
Linear Structural Formula: C22H25N3O2S
MDL Number: MFCD08868156
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: GSK1702934A (GSK-2934A) is a direct activator of TRPC3 and TRPC6 ion channels with selectivity for TRPC3. In HEK293 kidney cells transduced with recombinant human TRPC3 or TRPC6, GSK1702934A activated current with an EC50 of >= 80 nM for TRPC3 vs. 440 nM for TRPC6. It does not activate TRPV4, TRPA1, M1, M4, CaV1.2, hERG, NaV1.5, or CXCR5 receptors at concentrations<10 mum. gsk1702934a has been used to study trpc3 channels in the heart, exhibiting pro-arrhythmic, and inotropic actions in isolated langendorff hearts from trpc3-overexpressing mice.<>