Synonyms: [D-Ser(tBu)6,Azagly10]-LHRH acetate salt
CAS Number: 145781-92-6
Formula: C59H84N18O14
Formula Weight: 1269.41
Linear Formula: C59H84N18O14
MDL No.: MFCD01747329
Purity: >=99% (HPLC)
Storage: -20C
UNSPSC Code: 51111800
General description: Goserelin acetate is a synthetic decapaptide, which is a potent analog of LHRH (luteinizing hormone releasing hormone).
Amino Acid Sequence: Glp-His-Trp-Ser-Tyr-Ser(tBu)-Leu-Arg-Pro-azaGly-NH2
Biochem/physiol Actions: Goserelin acetate peptide results in significant inhibition of gonadotropin release and suppresses steroidogenesis in ovaries and testis. Thus, it leads to a reduction of testosterone to castration levels and estrogen to postmenopausal levels. Therefore, this peptide is used for reducing testosterone levels in patients with locally advanced prostate cancer.
Biochem/physiol Actions: Goserelin is a synthetic analog of LHRH (leutinizing hormone releasing hormone). Goserelin is a LHRH agonist It is used in prostate cancer and breast cancer therapies and also in the treatment of endometriosis.
RTECS: OK6369800
RIDADR: NONH for all modes of transport
WGK Germany: 3
Symbol: GHS08
Signal Word: Danger
Hazard Statements: H360
Precautionary statements: P201-P280-P308 + P313