Glutaminase Inhibitor 968 belongs to the benzophenanthridinone family.
Synonyms: 5-(3-Bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one
Molecular Formula: C27H27BrN2O
Molecular Weight: 475.42
Linear Structural Formula: C27H27BrN2O
Purity: >=98% (HPLC)
Storage: 2-8C
Application: Glutaminase inhibitor 968 has been used to study the role of glutamine metabolism in macrophage activation.
Biochem Physiol Actions: Variation in the 3-bromo-4-(dimethylamino)phenyl ring of glutaminase inhibitor 968, leads to loss of its inhibitory activity. Glutaminase catalysed glutamine metabolism maintains intracellular pH of cancer cells. Inhibition by glutaminase inhibitor 968 is known to hinder cell proliferation as a consequences of low intracellular pH.