Synonyms: Gentamicin sulfate salt
CAS Number: 1405-41-0
MDL No.: MFCD00270181
Storage: 2-8C
EC Number: 215-778-9
UNSPSC Code: 51101500
General description: Chemical structure: aminoglycoside
Application: Gentamicin sulfate, a broad-spectrum antibiotic, used as a selection agent (gentamicin-resistance gene) in cell culture and molecular biology applications. This product is recommended for use at 50 mg/L.
Biochem/physiol Actions: Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.
Components: Gentamicin is an aminoglycoside complex produced by fermentation of Micromonospora purpurea or M. echinospora. It is used as the sulfate salt. There are three components, each consisting of five basic nitrogens and requiresing five equivalents of sulfuric acid per mole of gentamicin base.
RTECS: LY2625000
RIDADR: NONH for all modes of transport
WGK Germany: 2
R Codes: 42/43
S Codes: 22-36/37-45
IOD Codes: Xn
Symbol: GHS07
Signal Word: Warning
Hazard Statements: H317
Precautionary statements: P280