Synonyms: N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine; ZD1839
Molecular Formula: C22H24ClFN4O3
Molecular Weight: 446.9
Linear Structural Formula: C22H24ClFN4O3
MDL Number: MFCD04307832
Purity: >=98% (HPLC)
Storage: room temp
Application: Gefitinib has been used :
•To study its effective use in endometrial cancer therapy
•Cell proliferation, cell cycle and apoptosis assays
•Cell viability assay and colony formation assay
Biochem Physiol Actions: Gefitinib is a selective epidermal growth factor receptor tyrosine kinase (EGFR TK) inhibitor. Gefitinib has antineoplastic activity, and has been approved for the treatment on non-small cell lung cancer (NSCLC).Gefitinib has a higher affinity for ATP (adenosine triphosphate) binding site in the EGFR tyrosine kinase domain than ATP. Hence, gefitinib is known to inhibit the progression of endometrial cancer.